another benefit to doing this in a city where some established botbrs have connections: we might be able to get a venue for free or cheap. plus a venue we get through more casual means won't be subject to as many annoying restrictions/costly permits (NOT THAT WE WOULD EVER PROMOTE SOMETHING LIKE UNDERAGE DRINKING WOW)
but seriously, it's not like we're likely to get rowdy enough that cops will get called (and this is not a challenge) ;) and not having to deal as much with rentals, permits, and those kind of logistics frees us up to spend our $/energies on more fun stuff, like custom arcade cabinets, projection displays, sound systems, flying in strobe and ui, etc etc. :)
so i vote detroit for that reason, or austin if puke has connections there. the only places i can really help with a venue like that would be boston or NYC, and those are not really very central. but another argument could be that if a lot of people are flying anyway, it doesn't really matter that much as long as it's in the US (because i let my passport expire ;_;)