One of those questions with no definitive answers. I'd say depends on your ultimate goals, if you just want to make music in general, rather than aiming for compatibility with specific vintage hardware, i'd say use any DAW (be it more or less modern, i personally love FL Studio, and you can also make a semi-competent MIDI with it).
You might also want to try with any sample-based tracker, like OpenMPT if you feel like you might like it more than piano-roll interfaces
In case of authentic music for old systems it's p much almost entirely a tracker-based workflow, most of the time though